Obesity

Prof. Giovanni Traverso speaks with GBH’s “All Things Considered” host Arun Rath about his work developing new approaches to weight loss treatments that don’t involve surgery or pharmaceuticals. “Our team does a lot of work on ingestible systems, ingestible capsules that can do many things,” says Traverso. “You know, we recognize that we live now in a world where we have really incredible therapies that are very effective for the treatment of diabetes and obesity. But we also recognize that they’re not for everybody. There are people who have side effects, people who can’t take them, so these are certainly alternatives, or potentially synergistic interventions, that could work together either with those drugs or, as I was mentioning, for folks that have side effects from the drugs.”

Researchers at MIT have developed a new type of dynamic gastric balloon that inflates on demand and could be used to help patients feel more full before meals, reports Margherita Bassi for Gizmodo. The engineers have “designed a potential future alternative for patients who, for any number of reasons, cannot treat obesity through medications or invasive surgeries such as gastric bypass surgery or stapling,” writes Bassi. 

Professor Giovanni Traverso and his colleagues have developed a new gastric balloon that can be inflated and deflated to mimic feeling full. Unlike traditional gastric balloons, which are one size, the new version is “connected to an external control device that can be attached to the skin and contains a pump that inflates and deflates the balloon when needed,” writes Ernie Mundell for HealthDay. 

MIT researchers have developed a gastric balloon that can inflate before eating and contract afterwards in an effort to ensure the body does not grow accustomed to the balloon, reports Nicola Davis for The Guardian. “What we try to do here is, in essence, simulate the mechanical effects of having a meal,” explains Prof. Giovanni Traverso. “What we want to avoid is getting used to that balloon." 

Dr. Sekar Kathiresan, a member of the Broad Institute of MIT and Harvard, speaks with NPR’s Richard Harris about his work on an experimental genetic scan that could identify people who are likely to become severely overweight. “This work hopefully will destigmatize obesity and make it very similar to every other disease, which is a combination of both lifestyle and genetics,” said Kathiresan.

STAT reporter Meghana Keshavan speaks with Prof. Guoping Feng about his new research that shows glial cells “very actively participate in direct neuronal function — particularly in the brain areas that control appetite, energy and metabolism.” The findings could help spur the development of weight loss medications. 

Lloyd Mallinson reports for Boston.com that researchers from MIT and Harvard have discovered the link between obesity and genetics. “The uncovered cellular circuits may allow us to dial a metabolic master switch for both risk and non-risk individuals, as a means to counter environmental, lifestyle, or genetic contributors to obesity,” explains Prof. Manolis Kellis.

Prof. Manolis Kellis speaks with BBC reporter Andrew Peach about the discovery of a genetic “master switch” inside fat cells. This switch “decides whether every time we have a meal the excess calories will be stored as fat or whether they will actually be burned away as heat,” explains Kellis.

Prof. Manolis Kellis and his colleagues have discovered a metabolic switch linked to obesity, reports Chukwuma Muanya for The Guardian. “Obesity has traditionally been seen as the result of an imbalance between the amount of food we eat and how much we exercise, but this view ignores the contribution of genetics to each individual’s metabolism,” explains Kellis.

“Researchers at MIT and Harvard Medical School have analysed the genetics behind obesity,” writes Natasha Hinde for The Huffington Post. “They discovered a new pathway that controls human metabolism by prompting fat cells to store fat or burn it away.”

Andy Coghlan reports for New Scientist that MIT researchers have found a gene that determines whether fat cells store or burn energy. “You could say we’ve found fat cells’ radiator, and how to turn it up or down,” says Prof. Manolis Kellis.

Alice Park reports for TIME that researchers from MIT and Harvard have identified a pathway that controls how much fat cells burn or store. “What these results say is that we can reprogram all the major fat stores in humans by intervening in this particular pathway,” explains Prof. Manolis Kellis.

Researchers from MIT and Harvard have discovered how the key gene linked to obesity makes people fat, reports the Associated Press. The study revealed that “a faulty version of the gene causes energy from food to be stored as fat rather than burned.”