How a mutation in microglia elevates Alzheimer’s risk
A new study finds that microglia with mutant TREM2 protein reduce brain circuit connections, promote inflammation, and contribute to Alzheimer’s pathology in other ways.
Aging Brain Initiative symposium showcases “cutting-edge” research across MIT
Seed projects, posters represent a wide range of labs working on technologies, therapeutic strategies, and fundamental research to advance understanding of age-related neurodegenerative disease.
A new wave of treatment for Alzheimer’s disease
Professor Li-Huei Tsai studies how brain waves can be used to treat neurodegenerative diseases such as Alzheimer’s.
2023-24 Takeda Fellows: Advancing research at the intersection of AI and health
Thirteen new graduate student fellows will pursue exciting new paths of knowledge and discovery.
Decoding the complexity of Alzheimer’s disease
By analyzing epigenomic and gene expression changes that occur in Alzheimer’s disease, researchers identify cellular pathways that could become new drug targets.
Molecule reduces inflammation in Alzheimer’s models
A potential new Alzheimer’s drug represses the harmful inflammatory response of the brain’s immune cells, reducing disease pathology, preserving neurons, and improving cognition in preclinical tests.
How Tau tangles form in the brain
A new study shows that truncated versions of the Tau protein are more likely to form the sticky filaments seen in the brains of people with Alzheimer’s disease.
Atlas of human brain blood vessels highlights changes in Alzheimer’s disease
MIT researchers characterize gene expression patterns for 22,500 brain vascular cells across 428 donors, revealing insights for Alzheimer’s onset and potential treatments.
From labs to the streets, experts work to defuse childhood threats to mental health
Symposium speakers describe numerous ways to promote prevention, resilience, healing, and wellness after early-life stresses.
40 Hz vibrations reduce Alzheimer’s pathology, symptoms in mouse models
Tactile stimulation improved motor performance, reduced phosphorylated tau, preserved neurons and synapses, and reduced DNA damage, a new study shows.
Neuroscientists identify cells especially vulnerable to Alzheimer’s
Neurons that form part of a memory circuit are among the first brain cells to show signs of neurodegeneration in Alzheimer’s disease.
A new peptide may hold potential as an Alzheimer’s treatment
The peptide blocks a hyperactive brain enzyme that contributes to the neurodegeneration seen in Alzheimer’s and other diseases.
Researchers map brain cell changes in Alzheimer’s disease
Study reveals key cell structures and gene expression changes near amyloid plaques and tau tangles in mouse brain tissue.
New technologies reveal cross-cutting breakdowns in Alzheimer’s disease
“Single-cell profiling” is helping neuroscientists see how disease affects major brain cell types and identify common, potentially targetable pathways.
Professor Emeritus Richard Wurtman, influential figure in translational research, dies at 86
Longtime MIT professor of neuroscience led research behind 200 patents, laying the groundwork for numerous medical products.